Award-winning physician Kenneth D. Nahum practices with Regional Cancer Care Associates (RCCA) as a hematologist and oncologist. Possessing more than three decades of experience, Dr. Kenneth D. Nahum has helped thousands of patients with various disorders, including hemophilia.
An inherited disorder on the X chromosome, hemophilia prevents the proper clotting of blood. Since women inherit two X chromosomes, one from each parent, they are less likely to develop hemophilia than men.
The presence of a second X chromosome prevents the development of this condition in many women, providing a second copy of the same genes. Men do not have this second copy since they have one X chromosome and one Y chromosome, which allows the mutated X chromosome to have more of an impact.
In most cases, women are carriers of hemophilia. However, about a third of these women also display mild hemophilia symptoms, such as impaired blood clotting. These women may have approximately 30 to 70 percent of the blood-clotting ability of someone who is not a carrier of the hemophilia mutation.
Carriers may experience heavy menstrual periods characterized by clots larger than a quarter, bleeding for more than seven days, or a large amount of blood that limits daily activities. Heavy bleeding from childbirth or dental surgery is also common among women who carry the hemophilia mutation.
Some women are diagnosed with hemophilia because they either inherited a mutated X chromosome from both parents, meaning they have two mutated X chromosomes, or their non-mutated X chromosome is either inactive or missing. This situation is extremely rare, but it does result in hemophilia symptoms similar to the symptoms in males with hemophilia.